The Identification and Characterization of a New Carbapenem CS-023 Solvate Polymorph Achieved by the Appropriate Crystal Washing and Drying

The solvation process of crystals is a complex parameter, especially for pharmaceuticals where the reproducible production consistent product paramount. novel carbapenem CS-023 with an ethanol/water system was challenging to determine. data were widely dispersed when ethanol/water-solvated washed crystallization solvent, requiring suitable washing and drying method be devised. To this end, industry-standard scrutinized, plausible mechanism established. Firstly, azeotropic solvent such as 96 wt% ethanol (although in experiment, v/v% employed) used solvent. Then, new polymorph CS-023, Form C (CS-023·EtOH·3H2O), successfully identified. observed produce steadily under 40–70 solution. relationship between A (CS-023·5/2EtOH·1/2H2O), which previously obtained 80 ethanol, investigated next. underwent solvent-mediated transformation ethanol.